The former Crytal Palace man was on the the Championship's most feared strikers last season and he showed his ability to step up by scoring early on against Jose Mourinho's side.
DeAndre Yedlin raced to the byline down the right and pulled the ball back to the penalty spot and Gayle did the rest, sweeping the ball into the far corner with a kiss off the post on the way through.
It was a fine finish from the striker, not that Mourinho looked too impressed on the touchline.
Check out the goal for yourself below:
Dwight Gayle Goal HD - Manchester United0-1Newcastle Utd 18.11.2017 https://t.co/jJCip2z67l#SofaScore #MNU #NEW
— Goals online (@G0als_0nline) 18 November 2017