Zinedine Zidane's side are looking to record their first La Liga win at the Bernabeu this season and are now 1-0 up thanks to the Spanish midfielder.
On 30 minutes, Ronaldo slipped a ball in behind the Espanyol defence for Isco to run onto, and he made no mistake as he poked past Lopez.
Take a look at the goal here:
Callo el primero en el bernabeu Gol de #ISCO GOL del madrid #halamadrid #laligabbva #realmadrid pic.twitter.com/jJLBfyKgfK
— ELIAS (@FutbolTotal323) 1 de outubro de 2017