The former Sevilla man has been out of action since breaking his nose in the Madrid derby against Atletico, but is now ready for a return to action.
Though he is over the worst of his injury, Ramos will wear a protective mask against Athletic Bilbao as Real look to return to something like their best form.
Jesus Vallejo, Marcos Llorente and Achraf Hakimi have all been left out of the squad for the game.
Gareth Bale will miss the match 'as a precaution', whilst Marco Asensio and Luca Zidane also remain unavailable.
Real Madrid's squad is as follows: Keylor Navas, Kiko Casilla, Moha, Dani Carvajal, Sergio Ramos, Raphael Varane, Nacho, Marcelo, Theo Hernandez, Toni Kroos, Luka Modric, Casemiro, Isco, Mateo Kovacic, Dani Ceballos, Cristiano Ronaldo, Karim Benzema, Lucas Vázquez and Borja Mayoral.
Estos son los 19 convocados para el partido contra el @AthleticClub en San Mamés. #RMLiga | #RMMovistar pic.twitter.com/sK5WmDp2zM
— Real Madrid C.F. (@realmadrid) 2 December 2017