Real: Nacho will most likely sit out the Madrid derby as he continues his battle to be fit for the return leg against Juventus but Lucas Vazquez, Gareth Bale, Raphael Varane and Marco Asensio should all return to the starting line-up.
Atletico: The visitors will be without defender Filipe Luis, who is sidelined for the rest of the season, but Kevin Gameiro and Fernando Torres are available.
Real Madrid boss Zinedine Zidane:
"Our obligation is to give everything in all games and aim for as many points as possible. Tomorrow is very important -- we must show we want to win and get the points.
"Atletico deserve to be in second, but we can cut the distance and we will try and do that. Everybody thinks La Liga is over already, but we cannot know that. We must keep giving everything in all games.
"We will go out as always, to go for the game. We cannot sit back or try and play any other way. We are up against a very good team, we know that, defensively and in attack. It will be a good game, and our intensity is very important."
Atletico Madrid manager Diego Simeone:
"We are who we are, and we will look for hard work as our base to play a big game.
"Madrid have, if not the best team in the world, the best squad in the world. They have done great to put together a squad better than Paris Saint-Germain, Manchester City or Barcelona. That is their strength. So whoever we play against tomorrow we will know very clearly what we must do."
Did you know?
Atletico have conceded just twice in their last four visits to the Bernabeu.
Form:
Last time around:
It was a very cagey affair at the Wanda Metropolitano in the first fixture in November with both sides managing just four shots on target between them as the tie ended goalless.
Score prediction: 1-0
Real possible XI: Navas; Marcelo, Varane, Ramos, Carvajal; Asensio, Casemiro, Modric, Vazquez; Bale, Ronaldo.
Atletico possible XI: Oblak; Hernandez, Godin, Savic, Juanfran; gabi, Niguez, Koke, Gameiro; Costa, Griezmann.